Evaluation of Antiulcer Activity of Picrasma Quassioides Bennett Aqueous Extract in Rodents

Abstract

The present study was focused to evaluate the protective activity of the Picrasma quassioides (PQ) whole plant aqueous extract against aspirin-pylorus ligation, HCl-ethanol and water immersion stress induced ulcers. In the present study aspirin-pylorus ligation induced gastric ulcer was adopted to screen the antisecretory activity of plant extract. PQ extract produced 64.63% ulcer inhibition at 400mg/kg body weight, when compared to that of standard (ranitidine, 50mg/kg) which produced 68.52% ulcer inhibition. In HCl-ethanol induced ulcer model 400mg/kg body weight of PQ produced 72.24% ulcer inhibition when compared that of standard (sucralfate, 100mg/kg) which produced 75.01% ulcer inhibition. In water immersion-stress induced ulcer model 400mg/kg body weight of PQ, produced 84.11% ulcer inhibition when compared to that of standard (omeprazole, 20mg/kg) which produced 82.17% ulcer inhibition. PQ showed significant percentage of ulcer inhibition in the three models tested. The glycosides which are present in the aqueous extract could be responsible for their antiulcer properties.