EVALUATION OF ANTITUSSIVE ACTIVITY OF VASU COUGH SYRUP IN SULPHUR DIOXIDE (SO2) INDUCED COUGH MODEL IN MICE

Abstract

Cough is the most common symptom of respiratory diseases. When cough becomes serious, opioid drug s are effective, but they have side effects like sedation, delirium, constipation etc. . Therefore, there is a need to search out effective anti - tussi ve agent s that are free from previously mentioned side effects . The present study was carried out to evaluate acute oral toxicity study and anti - tussive activity of Vasu Cough S yrup in sulphur dioxide (SO 2 ) - induced cough model in mice. Albino mice of eithe r sex, weighing 25 - 30 g were divid ed into four groups (n = 6). Group I served as Disease control, Group II received standard drug i . e. Codeine phosphate (10 mg/kg), p.o., group III to IV w ere given V asu Cough S yrup 0.25 mL /kg and 0.5 mL /kg body wt. p.o., dos e. After 30 minutes , the mice were exposed to S ulphur dioxide for 30 sec. The mice were then placed in an observation chamber for counting of cough bouts for five minutes. Vasu Cough S yrup showed 63.91% and 70.64% inhibition in frequency of cough at 0.25 mL /kg and 0.5 mL /kg dose level respectively. It proves significant anti - tussive activity of Vasu Cough S yrup in S ulphur dioxide induced cough model. Thus, Vasu Cough S yrup can be useful as an alternative medicine for cough .