Abstract
<strong>Objective:</strong> To study the antipyretic and anti-inflammatory effects of the Aqueous Extract of <em>Leptadenia Reticulata</em> (AELR) in different animal models. <strong>Materials and Methods</strong>: Acute toxicity studies were performed and extract was found to be safe upto 2000 mg/kg. Two doses were selected for the "evaluation of antipyretic and anti-inflammatory activity of aqueous extract of <em>Leptadenia reticulata</em> in animal models" i.e 200 mg/kg and 400 mg/kg b. w. Antipyretic activity was evaluated using baker's yeast induced pyrexia in albino rats and cow milk induced pyrexia in albino rabbits. Anti-inflammatory activity was evaluated using carrageenan induced paw edema and turpentine oil induced paw edema in albino rats. <strong>Results</strong>: In all the animal models AELR at the dose of 200 mg/kg b.w and 400 mg/kg b.w showed significant (P&lt;0.01) antipyretic and anti-inflammatory activity. <strong>Conclusion</strong>: These finding could justify the inclusion of aqueous extract of <em>Leptadenia reticulata</em> in the management of pyrexia and inflammation.
Highlights
The present study was designed to evaluate the effect of aqueous extract of the whole plant of Leptadenia reticulata on pyrexia and inflammation
Aqueous extract of the whole plant of Leptadenia reticulata was procured from GR Herbals extractions
The preliminary phytochemical screening of the aqueous extract of Leptadenia reticulata revealed the presence of sterols, triterpenoids, flavonoids, proteins and carbohydrates[5]
Summary
Pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neOubrojetrcatnivsem:itTtoersstusudcyhtahseGaanmtimpyar-eAtmicinaondBuatnytriic-inAfcliadm(GmAaBtAo)riyneefpfeilcetpssyofanthdeinApqsuyecohoussisEdxtorpaacmt oinfeL,enpotraadderenniaaliRneetiacnudlata (AELR) seinrotdoinffienrceonntteanntisminatlhmeoroddeelsn.t Mbraaitnewriearles easntidmMateedt.hTohdese:xAtrcaucteprteotxreicaitmy esntut dreiedsucwedermeapxeimrfaolremleectdroasnhdocekx;tIrsaocntiawziads found to (INbHe)saanfed Puepnttoyl2en0e0t0etmragzo/lkeg(.PTTwZ)oinddousceeds wseeizrueressealencdteadlsofosrigtnhifeica“netvlyaliunahtiiboitnedotfhaenattitpeynrueatiticonanodf barnatini-iGnAflBaAmlmevaetlos ry activity byofINaHquanedouPsTZeixntrmacicteo. Antisiginnfilfaicmanmtlyatroerdyuacecdtivleitvyewls aosf ebvraailnuadtoepdamusinineg, cnaorrraadgreeneanlianne ianndducseerdotpoanwinewdheimchamaanydbteurdpueenttionebloocilkiinngduocfecdenptarawl edema in dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. /kg b.w showed significant (P
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