Abstract
BackgroundPongamia pinnata (Fabaceae) is among those categories of plants mentioned in Ayurveda and traditionally known to use in several types of disease and disorders. The objective of the present work was to investigate the anti-psoriatic activity of Pongamia pinnata leaves extracts in Herbal gel formulation.ResultsHydroalcoholic leaves extract of Pongamia pinnata was first subjected to phytochemical screening and quantification of phytoconstituents. Herbal gel was prepared containing Pongamia pinnata extracts using Carbopol 934 as gelling agent. The prepared gel formulations were studied for pH, viscosity, Spreadability and in vitro diffusion studies. The imiquimod-induced psoriatic mouse model, showed a prominent anti-psoriatic activity of the extract as evident through index grading. Treatment with extract confirmed a noteworthy reduction in psoriasis in the treated groups as there was a considerable diminution in the thickness and scaling of skin.ConclusionsLack of proper treatment and disadvantages associated with allopathic medicines pave the way to extensive research in natural products with anti-psoriatic activity. The present research scientifically justified the anti-psoriatic activity of the Hydroalcoholic extracts of Pongamia pinnata leaves.
Highlights
Pongamia pinnata (Fabaceae) is among those categories of plants mentioned in Ayurveda and traditionally known to use in several types of disease and disorders
The pathogenesis of psoriasis is associated with increased production of inflammatory cytokines that cause hyperkeratosis [13, 19]
Plant material and extraction The leaves of Pongamia pinnata were procured from the local herbal habitat of Nagpur region, Maharashtra, India and were authenticated from Department of Botany, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
Summary
Pongamia pinnata (Fabaceae) is among those categories of plants mentioned in Ayurveda and traditionally known to use in several types of disease and disorders. The objective of the present work was to investigate the anti-psoriatic activity of Pongamia pinnata leaves extracts in Herbal gel formulation. The pathogenesis of psoriasis is associated with increased production of inflammatory cytokines that cause hyperkeratosis [13, 19]. Vulgaris (plaque) has reported to affects around 85%–90% of psoriatic patients affecting physically and mentally a lot [7, 12]. Most scientist and researchers have worked on various extracts and chemical constituents, and reported the antioxidant, antimicrobial, antiparasite, anti-inflammatory, anti-convulsant, anti-diabetic, antihyperammnonemic, cytotoxicity, anthelminthic, insecticidal and immunomodulatory activities [1]
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