Abstract
BackgroundWithout doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research.MethodsThis work progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with pharmacological activities. In the present study we investigated the efficacy of methanol extract and its semi-purified fractions (F2, F3) from Spongia officinalis for their in vivo anti-inflammatory activity using the carrageenan-induced paw edema in rats and their in vitro antiproliferative effects by their potential cytotoxic activity using the MTT colorimetric method and clonogenic inhibition against three human cancer cell lines (A549, lung cell carcinoma, HCT15, colon cell carcinoma and MCF7, breast adenocarcinoma).ResultsThe fractions F2 and F3 showed interesting anti-inflammatory and antiproliferative activities in a dose dependent manner.ConclusionsThe present study indicates that the methanolic extrac and its fractions from Spongia officinalis are a significant source of compounds with the antiproliferative and anti-inflammatory activities, and this may be useful for developing potential chemopreventive substances.
Highlights
A variety of ingredients of traditional medicines and herbs are being widely investigated in several parts of the world to analyze their potential as therapeutic agents [1,2,3]
The objective of the present study was to evaluate the potency of methanol extract and its semi-purified fractions (F2, F3) from Spongia officinalis for inhibiting inflammation induced by carrageenan and for growth and clonogenic inhibiting of three human cancer cell lines A549, HCT15 and
Carrageenan induced rat paw edema The anti-inflammatory activity of our extract and fractions on carrageenan-induced paw edema was determined according to Winter et al [12]
Summary
A variety of ingredients of traditional medicines and herbs are being widely investigated in several parts of the world to analyze their potential as therapeutic agents [1,2,3]. Since the few last decades, marine environment have been recognized to be a rich sources of bioactive metabolites with varied biological and pharmacological activities [4,5]. The most interesting phyla with respect to pharmacological active marine compounds include bacteria, fungi, algae, soft corals and gorgonians, sea MCF7 with the aim of identifying novel molecules with interesting and potentially useful pharmacological activities. Natural products have been, and still are, the cornerstone of the health care armamentarium. The marine environment is clearly the last great frontier for pharmaceutical and medical research
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