Abstract
The medicinal properties of plants have been investigated in the recent scientific world because of their potent antioxidant activities, mild side effects and economic viability. This study evaluated the antioxidant property and antidiabetic effect of ethanol seed extract of G. kola (bitter kola) on alloxan induced diabetic albino rats. The in-vitro antioxidant assay was done using standard methods. Thirty (36) albino rats were used for the in-vivo study and fasted for 16-18hours and thereafter induced diabetes with 150mg/ kg b.w. of alloxan monohydrate via intraperitoneal injection. The animals were divided into six groups of six (6) rats each. Group A was the normal control, group B was the positive control (treated with 5mg/kg b.w of glabeclamide), Group C was the negative control (untreated) and groups D through F were administered 500mg/kg, 250mg/kg and 125mg/kg of the extract respectively. The results showed 49.70% reduction in blood glucose level of the 500mg/kg extract treated group compared to the positive control (45.03 %) on the day 7. The antioxidant results showed a significant (p<0.05) dose dependent increase in its ability to scavenge free radicals. The results of this study suggested the use of G. kola seed for the treatment of free radical mediated diseases and management of diabetes.
Highlights
Diabetes mellitus (DM) is a metabolic disorders in which there are high blood sugar levels over a prolonged period [1,2]
This study evaluated the antioxidant property and antidiabetic effect of ethanol seed extract of G. kola on alloxan induced diabetic albino rats
The results of this study suggested the use of G. kola seed for the treatment of free radical mediated diseases and management of diabetes
Summary
Diabetes mellitus (DM) is a metabolic disorders in which there are high blood sugar levels over a prolonged period [1,2]. Continuous use of the synthetic anti-diabetic drugs causes side effects and toxicity [17] Antioxidants such as thiols or ascorbic acid (vitamin C) terminate chain reactions. The continuous exposure to chemicals and contaminants may lead to an increase in the amount of free radicals in the body, beyond its capacity to control them, and can cause irreversible oxidative damage [23], that is why exogenous antioxidant especially from plants are very crucial. This present study is designed to evaluate the antioxidant properties and antidiabetic effect of ethanol extract of Garcinia kola
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