Abstract
Natural products gain more attention nowadays because of their compatibility with mankind, safe and economic feasible. The main purpose of this study was to evaluate antioxidant, cytotoxic and apoptotic activities of methanolic extract of Momordica cymbalaria Hook F. unripe fruit (UF). A considerable DPPH, hydroxyl radical scavenging and metal ion chelating activities and significant inhibitory effect on lipid peroxidation and least activity on deoxyribose degradation was observed for methanolic UF extract. Cytotoxic activity of UF extract on HeLa cells was observed and its inhibitory concentration fifty percent was calculated as 17.69±0.01µg/mL. Apoptosis inducing ability of UF extract on HeLa cells was also observed by Propidium iodide and acridine orange/ethidium bromide (AO/EtBr) dual staining. This is the first report on antioxidant, cytotoxic and apoptotic inducing ability of methanolic UF extract of Momordica cymbalaria collected from Sattur, Virudhunagar district, Tamilnadu, India.
Highlights
IntroductionCervical cancer is considered to be the most commonly found cancer in women which leads to high mortality rate [1]
In developing countries, cervical cancer is considered to be the most commonly found cancer in women which leads to high mortality rate [1].Currently many studies were carried out to screen active constituents from plants for treating cancer [2]
A considerable DPPH, hydroxyl radical scavenging and metal ion chelating activities and significant inhibitory effect on lipid peroxidation and least activity on deoxyribose degradation was observed for methanolic unripe fruit (UF) extract
Summary
Cervical cancer is considered to be the most commonly found cancer in women which leads to high mortality rate [1]. Many studies were carried out to screen active constituents from plants for treating cancer [2]. It is important to develop the natural plant based agents which induce cytotoxicity and apoptosis in cancer cells [3]. Cymbalaria contains high levels of calcium, potassium and vitamin C [4]. It has a wide range of medicinal properties like cardioprotective, hepatoprotective, nephroprotective and antioxidant [5]. Based on the medicinal importance of M. cymbalaria, the present study was designed to evaluate antioxidant, cytotoxic and apoptosis inducing activities of methanolic unripe fruit extract
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