Evaluation of Antioxidant, Anti-Inflammatory, Antibacterial Activity and In Silico Molecular Docking Study of Pyrazole Curcumin Bisacetamide Analogs

Abstract

A series of pyrazole curcumin bisacetamides (4 a-l) were synthesized with excellent yield and in vitro antioxidant, anti-inflammatory and antibacterial activities were studied. These compounds have shown marvelous antioxidant and anti-inflammatory activities towards curcumin and standard drug. The compounds 4 d, 4 j, 4 l, have shown better antibacterial activity than ciprofloxacin and parent curcumin in both gram-positive and gram-negative bacterias. The compounds 4 j, 4 k, and 4 l have exhibited very good activity on methicillin-resistant staphylococcus aureus when compared to standard oxacillin and parent curcumin. Further, the molecular docking studies revealed that the compounds 4 d and 4 l have shown better binding interaction with penicillin binding protein via five hydrogen bond interactions.