Abstract
The phytochemicals, antioxidants, antiinflammatory and the anti-hyperglycemic properties of Wattakaka volubilis Linn. F were determined. The Hot Water Extract (HWE) and Acetone Extracts (AE) of W. volubilis leaves were tested for a variety of phytochemicals. The preliminary analysis revealed the presence of a large number of phytochemicals. The DPPH assay was used to measure the free radical scavenging activity of both HWE and AE. The HWE had the highest DPPH scavenging rate (87.72 %t), followed by the AE (33.33 %). At 500 g/mL concentration, the anti-inflammatory activity of HWE, AE, and Diclofenac (standard drug) was 54.27 %, 49.88 %, and 83.33 %, respectively. Orally administered alloxan (75 mg/kg body weight) resulted in a significant (p 0.05) decrease in blood glucose levels in diabetic mice with HWE and AE at 200 mg/kg b.wt for 4 weeks. Aside from all hypoglycemic parameters, the histopathology of the pancreas was also controlled, indicating that HWE exerted greater anti-diabetic activity than AE. Furthermore, HWE supported a significant inhibition of -amylase enzyme activity, with the highest action of 99.23 % reticence at 1000 g/mL. The findings indicate that HWE has a potential antidiabetic effect; thus, HWE may be a non-hazardous traditional and complementary medicine in treating hyperglycemia and related problems, substantiating as an anti-hyperglycemic agent.
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