Abstract
This study revealed the antioxidant and anticancer activities of the ethanolic extract of the tender fruits of Cocos nucifera. In antioxidant screening, IC50 value was found to be 7.71μg/mlfor ascorbic acid and44.67 μg/ml for C. nucifera fruits. The phenolic content, total flavonoid and total tannin content were 537.89 mg GAE/100 gm, 40.69mg of QE/100 gm and 44.61 mg of GAE/100 gm of dry powder of C. nucifera respectively. In DMBA and croton oil-induced skin cancer in model mice,the extract significantly decreased the number, size, yield and burden of tumor when compared with carcinogenic control. The extract increased the level of natural antioxidants like GSH, SOD and Catalase. Moreover, substantial decrease in SGPT, SGOT (liver activity marker) was observed at different doses ofthe crude extract. Lipid profile of mice treated with C. nucifera was brought back to normal level to some extent when compared to carcinogenic control. In conclusion,C. nucifera fruits have antioxidant activity as well as preventive role on cancer initiation and propagation without major toxicity.Jahangirnagar University J. Biol. Sci. 6(2): 47-58, 2017 (December)
Highlights
Cancer is one of the most life-threatening diseases, with more than 100 different types occurring due to some molecular changes within the cell
Sample Collection: The fruits of Cocos nucifera were collected from surrounding area of Khulna university
Drying & Grinding: The collected fruits were air dried for three weeks and were ground into a fine powder with the help of a suitable grinder
Summary
Cancer is one of the most life-threatening diseases, with more than 100 different types occurring due to some molecular changes within the cell. It is the third leading cause of death worldwide following cardiovascular and infectious diseases. Cancer is the second leading cause of death globally, and was responsible for 8.8 million deaths in 2015. Nearly 1 in 6 deaths is due to cancer. The disease is widely prevalent, and in the West, almost a third of the population develops cancer at some point of time during their life. The mortality due to cancer is high, many advances have been made both in terms of treatment and understanding the biology of the disease at the molecular level (Swerdlow et al, 2010)
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