Evaluation of antioxidant and anti-inflammatory activity of Euphorbia heyneana Spreng

Abstract

Objective To assess the antioxidant and anti-inflammatory activities of the alcoholic extract of Euphorbia heyneana ( E. heyneana) in carrageenan induced inflammation in rats. Methods In vitro antioxidant activity was evaluated for superoxide radical, hydroxyl radical and DPPH radical scavenging activity. Three doses 200, 400 and 800 mg/kg were tested for anti-inflammatory activity in carrageenan induced rat paw oedema model and paw thickness was measured every one hour up to 6 hours. Results The alcoholic extract of E. heyneana produced dose dependent inhibition of superoxide radical, hydroxyl radical and DPPH radicals. In carrageenan induced inflammation model, all three doses produced significant percentage inhibition of rat paw oedema and 800 mg/kg dose produced maximum percent inhibition of rat paw oedema (47.06%) among the three doses compared to control group. Conclusions It can be concluded that alcoholic extract of E. heyneana shows good in vitro antioxidant and in-vivo anti-inflammatory activities in rats.