Abstract
Antioxidant activity of petroleum ether, chloroform, ethyl acetate and methanol extracts of leaf, stem and root of Mimosa pudica L. was observed through DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging assay. Five concentrations (12.5, 25.0, 50.0, 100.0 and 200.0µg/ml) were taken for each extract as well as the standard and the absorbances were measured at 517nm using a spectrophotometer against methanol blank. The activity was increased by the increment of concentrations of the extracts. In case of leaf, the highest scavenging percentage was found in chloroform extract (86.40%) at 200.0µg/ml concentration. But for stem and root, the highest scavenging percentages were found in ethyl acetate extracts (73.72% and 83.79% respectively) at same concentration. The ethyl acetate extracts showed the highest activity among all the extracts where the IC50 values were 65.152µg/ml, 76.036µg/ml and 65.000µg/ml and the lowest was found in petroleum ether extracts where the IC50 values were 130.129µg/ml, 147.891µg/ml and 186.449µg/ml for leaf, stem and root respectively and that was for ascorbic acid (standard) was 18.012µg/ml.
Highlights
Plants contain bioactive constituents that are used as traditional medicines as well as modern medicine and these natural compounds are used for phytotherapy and pharmaceutical drugs (Sahu et al 2015)
The damage of cells are prevented by the antioxidants significantly by scavenging the free radicals and reactive oxygen species developed in different diseases as hepatic failure, diabetes mellitus, renal failure, atherosclerosis, inflammation, cancer, etc. (Bulkley 1983, Halliwell and Gutteridge 1993, Niki 1995 and Frei 1999)
In the present study the antioxidant activity of different solvent extracts of M. pudica was evaluated at different concentrations
Summary
Plants contain bioactive constituents that are used as traditional medicines as well as modern medicine and these natural compounds are used for phytotherapy and pharmaceutical drugs (Sahu et al 2015). A large number of factors such as xenobiotics, radiation or exposure to heavy metals are responsible for inducing oxidative stress and enhancing the production of free radicals (Shinde et al 2016). The consumption of antioxidant rich diet may prevent the oxidative stress induced degenerative diseases (Habib and Ibrahim 2011, Hendra et al 2011 and Gulcin 2012). The present study serves as a basis for further research to isolate the bioactive compounds for discovery of new herbal drugs
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