Evaluation of antioxidant activity in without persistent ST-segment elevation

Abstract

Aims: Coronary artery disease is the most common cause of mortality and morbidity worldwide. Oxidative stress is involved in the pathogenesis of many diseases, including atherosclerosis. Thiols are important antioxidants for the elimination of reactive oxygen radicals and oxidative stress. In this study, we aimed to compare patients suffering from without persistent ST-segment elevation (NSTMI) and volunteers with normal coronary arteries in terms of antioxidants. Methods: The study included 105 patients diagnosed with NSTMI and 51 controls. Plasma total thiol, native thiol, and disulfide levels were measured. Results: Baseline demographic characteristics were similar between the groups. The ejection fraction was lower in the patient group. In terms of biochemical and hematologic parameters, glucose, AST, ALT, white blood cell count, and troponin were higher in the patient group, while other parameters were similar. Plasma native thiol (344.32 ± 81.28 µmol/L versus 403.62 ± 62.36 µmol/L, p < 0.0001) and total thiol (382.90 ± 91.13 µmol/L versus 444.17 ± 65.53 µmol/L, p < 0. 0001) levels were lower in NSTMI patients compared to control patients, while disulfide (19.29± 3.19 versus 20.27± 8.10, p = 0.77) levels were similar between the groups. Conclusion: In this study, we found that native thiol and total thiol levels, which are antioxidant markers, were lower in patients with NSTMI compared with the control group. Our study shows that antioxidant activity is affected in NSTMI, and antioxidant levels are decreased.