Abstract
BackgroundObesity, reached epidemic proportions globally is often associated with life threatening comorbidities. The unavailability of safe and effective long term medications for obesity in modern pharmacotherapy forces the scientific community to explore the potential of Ayurvedic traditional healers as they are considered safe and effective.ObjectiveTo explore the anti-obesity potential of aqueous extract of aerial parts of Achyranthes aspera L. (AEAA), a traditional healer in high fat diet (HFD) induced obese rats.MethodsAEAA was prepared and subjected to in-vitro pancreatic lipase inhibition assay and in-vivo anti-obesity studies. For in-vivo studies, HFD fed obese prone Wistar albino rats were divided into five experimental groups (Group II to VI): animals fed with standard pellet chow served as normal control (Group I) while, animals continued with HFD alone served as obese control (Group II); Group III, IV and V were administered AEAA at a dose of 100, 200 and 300 mg/kg b.w. respectively along with HFD; and animals administered orlistat (30 mg/kg bw) along with HFD served as standard control (Group VI). All the drugs were administered orally once a day for a period of 60 days. At the end of the experimental period various physical, biochemical and histopathological observations were made.ResultsIn-vitro studies showed AEAA partially but not significantly inhibited the activity of pancreatic lipase. Data of in-vivo studies revealed, significant reduction in body weights, fat pad weights and organ weights upon AEAA treatment. Elevated levels of glucose, insulin, leptin, lipid profiles and antioxidant status were also brought back to normal.ConclusionThe obtained results clearly suggested that AEAA possess pronounced anti-obesity potential.
Highlights
Obesity is a chronic, multifactorial medical condition characterized by excess body fat that develops as a result of long-term energy imbalance i.e., excessive caloric consumption and insufficient energy output
The obtained results clearly suggested that Achyranthes aspera L. (AEAA) possess pronounced anti-obesity potential
Effect of AEAA on in-vitro pancreatic lipase inhibition activity The AEAA was studied for its in-vitro pancreatic lipase inhibitory activity and the effect was compared with standard drug Orlistat
Summary
Multifactorial medical condition characterized by excess body fat that develops as a result of long-term energy imbalance i.e., excessive caloric consumption and insufficient energy output. There are so many approaches are followed currently to control overweight and obesity such as lifestyle modification, including dieting and physical exercise to shed extra calorie, antiobesity drugs to reduce appetite or inhibit fat absorption and bariatric surgery to earlier satiation and reduce ability to absorb nutrients from food [3]. All these interventions have very modest efficacy in bringing weight loss. The unavailability of safe and effective long term medications for obesity in modern pharmacotherapy forces the scientific community to explore the potential of Ayurvedic traditional healers as they are considered safe and effective
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