Evaluation of anti-nociceptive activity of Cissus quadrangularis on albino mice

Abstract

Th roughout the history, man has used several forms of therapy for relief of pain; among them, medicinal herbs have gained popularity because of its wide use and less side eff ects. Cissus quadrangularis, for example, is a commonly used folklore medicine in India to hasten the fracture healing process; in Cameroon, the whole plant is used for the treatment of oral dehydration, while in Africa and Asia, the leaves, stems and roots are utilized for the treatment of various ailments. Th e plant extract were prepared by using chloroform and distilled water in proportion (20:80), macerated for 72 h with occasional stirring and concentrated under dry vacuum. Th e extract of Cissus quadrangularis was examined for centrally acting analgesics by using the hot plate method, formalin test and acetic acidinduced writhing method for peripherally acting analgesics. Th e doses administered were 250 mg/kg and 350 mg/kg. Th e animal that administered both the doses showed signifi cant analgesic activity. Th e animal that administered a dose of 350 mg/kg has shown the maximum analgesic activity which is comparable to the standard. Key words: Analgesic, Cissus quadrangularis, formalin, writhing