Evaluation of Antineoplastic Activity of Aloe vera latex extract on Human Hepatic Cancer Cell Line

Abstract

Liver cancer is one of the most common fatal types of cancer over the world. Conventional cancer treatments such as surgery, chemotherapy and radiation therapy are costly and requires long-term commitment to be effective, which eventually leads to financial burden and suffering of patients and their families. Natural extracts originated from plants have been studied and exploited as pharmaceutical products or functional products supporting cancer treatments for years. The purpose of this study is to evaluate the antineoplastic activity of Aloe vera on Huh-7 cell line. The results showed that dimethyl sulfoxide extract from Aloe vera latex had cytotoxicity on Huh-7 cell line after 24-48 h of treatment with IC50 value at (160.72 ± 2.95) µg/mL and (156.41 ± 1.30) µg/mL respectively. Besides, the extract also inhibited the migration of cancer cells in 24-48 h treatment at minimum concentration of 100 µg/mL. Hence, Aloe vera latex extract is considered a potential anticancer agent against the proliferation of hepatic cancer cell. ® 2022 Journal of Science and Technology - NTTU