Evaluation of Antimicrobial Susceptibility Among Acintobacter baumannii by E-Test Method at Khatam-Al-Anbia Hospital During 2013 - 2015

Abstract

Background: Nosocomial infections are one of the health problems of modern societies, which are rising with unusual organisms. Acintobacter, which is the main cause of nosocomial infections such as pneumonia and nosocomial pneumonia, is caused by mechanical ventilation. Acinetobacter species are becoming resistant to antibiotics. One the most important agent of nosocomial infections with high mortality is infections by Acinetobacter baumannii which is Gram- negative opportunistic Coccobacilli. Treatment in these infections is difficult and sometimes impossible, due to multidrug resistance in strains isolated from nosocomial infections. Objectives: The aim of the current study was to evaluate antibiotic resistance in A. baumannii isolates Khatam-Al-Anbia Hospital, Tehran, Iran. Methods: In this cross-sectional study 100 of Acintobacter baumannii were isolated from hospitalized patients during 2013-2015 in Khatam-Al-Anbia hospital in Tehran. In this study samples of A. baumannii isolated from trachea, blood, urine, sputum and wound samples of patients bedridden in Intensive care unit (ICU) wards. Antimicrobial susceptibility and minimum inhibitory concentration (MIC) were determined by E-test methods. We used descriptive statistics to analyze the data by using SPSS 21 software. Results: A total of 100 A. baumannii were isolated from clinical samples. The organism was resistant to rifampicin (46%), gentamicin (67%), meropenem (100%), piperacilin (98%), colistin (0%), and ceftazidin (96%). Conclusions: The antibiotic resistance against most of the antibiotics especially meropenem is very high in this study. Moreover, colistin was most effective antibiotic to be used in A. baumannii infections. Colistin is the best choices for treatment of Acinetobacter.