Abstract
Antimicrobial activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter pylori isolated from ulcer patients in Ondo State, Nigeria were investigated. Hot water, cold water and two organic solvents (Pet ether and Ethanol) were used for the extraction with the highest yield being the ethanolic extracts of Carica papaya with 17.2%, while cold water extract of both Carica papaya and Azadirachta indica (Neem) extracts had 15.6% and 11.6% respectively. The result shows that the Carica papaya, Azadirachta indica and Moringa oleifera leaves extract had antimicrobial effect on the H. pylori isolated from ulcer patients in Ondo State, Nigeria. Moringa oleifera leaves showed some remarkable effect on H. pylori with the ethanolic extract of Carica papaya being the most potent. In comparison, the ethanolic extract had the highest level of antimicrobial activity than pet ether, cold and hot water extracts. The results of this study showed that leaf extracts of C. papaya, A. indica and M. oleifera had a very high microbial action on the isolates. The results of this study clearly suggest that leaf extracts of C. papaya, A. indica and M. oleifera leaves act as potent growth inhibitor of H. pylori. The emergence of resistance of microorganism to current first line therapy required vigorous research for substitute antimicrobial. The plants used in this study could serve as qualified plants in drug production. There is need for vigorous research to be done on the purification of these crude extracts for the development of new antibiotics to combat the infections caused by these resistant strains.
Highlights
An ulcer is basically an inflammed break in the skin or in the mucus membrane lining the gastrointestinal tract [1]
62 Morufu Adesina Bakare and Anthony Kayode Onifade: Evaluation of Antimicrobial Activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter Pylori Isolated from Ulcer Patients in Ondo State, Nigeria
The aim of this study was to evaluate the antimicrobial activities of Carica papaya, Azadirachta indica and Moringa oleifera on Helicobacter pylori isolated from ulcer patients in Ondo State, Nigeria
Summary
An ulcer is basically an inflammed break in the skin or in the mucus membrane lining the gastrointestinal tract [1]. Peptic ulcer is one of the most common disorders of the gastrointestinal system which causes discomfort to the patients, disrupting their daily routine and causes mental distress [2]. About 70% of patients with peptic ulcer diseases are infected by bacterium H. pylori [4]. Up to 60% of peptic ulcers are associated with H. pylori infection of the stomach. Last two decades have witnessed introduction of a number of new drugs for the treatment of peptic ulcers. None of these drugs are free from toxicities. Efforts have been made to find suitable alternative remedies from plant and animal origins for the treatment of peptic ulcer [3]
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