Abstract
Naproxen is a nonsteroidal anti-inflammatory drug, it has analgesic, anti-inflammatory and antipyretic effect by inhibiting prostaglandin synthesis via inhibition of cyclooxygenase enzymes. This study was designed to evaluate analgesic and Anti-inflammatory effect of optimized NANEs (Non-aqueous Nano Emulsion) of Naproxen in experimental animals. The anti‐inflammatory activity of the optimized NANEs of Naproxen was evaluated using right hind paw oedema size of rats induced by carrageenan injection and analgesic effect was evaluated using Hot Plate method and Tail-flick method applied on rats. Results related to the anti‐inflammatory activity revealed that the optimized NANEs of Naproxen produced a maximum percent oedema inhibition as compared to standard naproxen formulation. Similarly, the analgesic effect of the optimized NANEs of Naproxen shows better effect as compared to marketed formulations. Finally, this study concludes that the tested Optimized NANEs of Naproxen exhibited good and acceptable anti-inflammatory and analgesic effect in comparison to the commercial marketed formulation.
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