Evaluation of antifungal effect of maxillofacial silicone after incorporation of chitosan nanoparticles: Evidence in pharmaceutical therapeutics

Abstract

Background: The incorporation of nanotechnology in dentistry is evident, especially in the past decade. The pharmaceutical research in nanotechnology has been a most important invention while considering its application in dental materials. The evidence gathered from the various pharmacotherapeutic researches on the incorporation of chitosan nanoparticles (NPs) to improve the antimicrobial activity of various dental materials are proved, although there is very less evidence of use of functionalized materials to improve its efficacy in clinical situations. Aim: The aim of the study was to evaluate the antifungal effect of maxillofacial silicone after incorporation of chitosan NPs in patients with maxillary defect. Objectives: The objective of the study was to compare the effectiveness of antifungal activity of silicone by incorporating chitosan NPs to that of the control group at various time intervals. Materials and Methods: Chitosan NPs were incorporated in silicone material for relining of interim obturator to check its efficacy with that of conventional interim obturator. Results: Experimental group of patients in which obturator is relined with silicone material consists chitosan NPs has shown to be more effective against fungal colonization growth as compared to that of control group. Conclusion: Chitosan NP with silicone maxillofacial material proved its efficacy against candida growth in patients of maxillary defects at various time intervals.