Abstract
Depression is a global problem associated with multiple social and health issues. In the present study, we analyzed the antidepressant effects of Lavandulifolia stachys, an herbal planton forced swimming test (FST). In this study, 36 rats were used. We gavaged the aqueous extract of plant (50, 100, 150 mg/kg), imipramine and fluoxetine (20 mg/kg) as standard antidepressant drug and normal saline for control group for a week. Then, their behavioral responses including climbing, swimming and immobility were recorded during the 5-min FST. Our experiments showed significant effects of Lavandulifolia stachys on swimming and immobility but not effect on climbing behaviors. Imipramine and fluoxetine increased climbing and swimming, respectively, and both reduced immobility, compared to saline control. Finally, our results show the extract of Lavandulifolia stachys could play an important role in treatment of depression like fluoxetine.
Highlights
Introduction were placed in water for15 minutes followed 24 hrs later by a 5-min test the
Dunnett t test indicated that doses of 50, 100, 150 mg/kg of the extract significantly caused a reduction in immobility (5.16, 3.8, 5 respectively) and an increase in swimming (24.3, 23.5, 26 respectively), compared to control group (P
Feelings and enjoying the life that climbing and swimming and reduction in tionally in surgical dressing for wounds, afflicts several millions of the world popu- immobility were considered as behavioral sedative-hypnotic, strengthening the memolation.[1,2]. It seems that signs and symptoms responses consistent with an antidepressant- ry and relief of stress, anti-inflammatory of depression are associated with decreased like action
Summary
Lavandulifolia Stachys were obtained from a local market in yasuj, Iran. It was authenticated by Department of Pharmacology, College of Science, Yasuj University. Dried leaves of the plant were converted to a fine powder. The powdered leaves (260 g) were macerated in a container with distilled water (500 mL) at room temperature for 48 hrs. Male Wistar rat (n=36), 240±20 g were obtained from the Animals House, Tehran University of Medical Sciences. The Rats were in cages of 5 at 22±1°C and had free access to water and food. 2019 Licensee PAGEPress srl, Italy International Journal of Plant Biology 2019; 10:7458 doi:10.4081/pb.2019.7458 between the means of these parameters were compared using by using ANOVA test
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