Abstract
Objective:To evaluate antidepressant like effect of tramadol in mice.Materials and Methods:Tramadol was administered at three different doses (10,20 and 40 mg/kg, i.p) once daily for 7 days to Swiss albino mice of either sex. The immobility period of control and drug treated mice were recorded in tail suspension test (TST).The antidepressant effect of tramadol was compared to that of fluoxetine (20 mg/kg, i.p), administered for seven days.Results:Tramadol produced significant antidepressant effect at all the doses, as indicated by reduction in immobility times as compared to control. The efficacy of tramadol at doses of 20 and 40 mg/kg was comparable with that of fluoxetine. Tramadol at 10 mg/kg dose showed significantly less antidepressant activity compared to fluoxetine. Conclusion:The results of the present study indicate antidepressant like activity of tramadol.
Highlights
Tramadol is a synthetic centrally acting opioid analgesic used mainly for the treatment of moderate to severe pain.[1]
The immobility period of control and drug treated mice were recorded in tail suspension test (TST).The antidepressant effect of tramadol was compared to that of fluoxetine (20 mg/kg, i.p), administered for seven days
The results of the present study indicate antidepressant like activity of tramadol
Summary
Tail suspension test: This animal model for testing antidepressant activity is based on the principle that suspending mice suspended upside down leads to a characteristic behavior of immobility after initial momentary struggle. [1,5,13] it could be inferred from our study that tramadol by acting through a similar mechanism (inhibition of reuptake of monoamines leading to spinal inhibition of pain) might add a component of mood elevation to its analgesic effect. This needs to be verified in different models of depression
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