Abstract
Acute appendicitis is an infection that occurs in vermiform appendix, and because of that it needs to do appendectomy immediately. Appendectomy is included in clean contaminated operation category which allows Surgical Site Infection (SSI). The antibiotics use in post-surgical patients to prevent the infections. The aims of this study to identify profile and determine the quantity and quality of antibiotics use. This study used cross sectional study with retrospective data on patient’s medical records after surgery for acute appendicitis in General Hospital Pasuruan Regency on January-December 2018. Data analysis was performed descriptively. The result of this study showed that the highest profile of the antibiotic use for mono therapy was Cefuroxime (25.81%) and for combination therapy were Phosphomycin + Metronidazole (8.06%) and Ceftriaxone + Metronidazole (8.06%). The quantity of antibiotics use by using Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) method was obtained total DDD value 52.01 DDD/100 patient-days with the highest antibiotic was Metronidazole parenteral route 14.00 DDD/100 patient-days. Antibiotics included in Drug Utilization 90% (DU 90%) segment were (Metronidazole, Ceftriaxone, Phosphomycin, Cefuroxime, Gentamicin) by parenteral route. The quality of antibiotics use based on the Infectious Disease Society of America (IDSA) Guidelines, appropriate indication (11.86%), appropriate dose (52,54%), appropriate interval (22,03%), appropriate route (96.61%) and appropriate duration of treatment (28.81%).
Highlights
The result of this study showed that the highest profile of the antibiotic use for mono therapy was Cefuroxime (25.81%) and for combination therapy were Phosphomycin + Metronidazole (8.06%) and Ceftriaxone + Metronidazole (8.06%)
Diagnosis and Management of Complicated Intraabdominal Infection in Adults and Children: Guidelines by The Surgical Infection Society and The Infectious Diseases Society of America
Summary
Apendisitis merupakan peradangan apendiks yang membahayakan jiwa jika tidak segera ditangani, terjadi infeksi berat yang dapat menyebabkan lumen usus pecah.[1]. Hasil evaluasi penggunaan antibiotik ini penting karena berperan sebagai indikator mutu Program Pengendalian Resistensi Antibiotik (PPRA) yaitu meningkatnya ketepatan penggunaan antibiotik dan menurunnya jumlah konsumsi antibiotik.[11] Berdasarkan penelitian yang dilakukan oleh Zulfikar (2014) tentang studi penggunaan antibiotik pada kasus bedah apendiks di instalasi rawat inap RSD dr. Evaluasi kualitatif dilakukan dengan menilai beberapa kriteria antara lain tepat indikasi, tepat dosis, tepat interval, tepat lama pemberian dan tepat rute.[11] Dengan demikian penelitian ini bertujuan untuk mengidentifikasi profil dan mengetahui kuantitas serta kualitas penggunaan antibiotik pada pasien pascabedah apendisitis akut di RSUD Kabupaten Pasuruan tahun 2018. RSUD tersebut juga memiliki program pengendalian resistensi antibiotik sehingga evaluasi penggunaan antibiotik penting dilakukan demi mendukung program tersebut
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