Evaluation of antibacterial activity and wound healing of Pistacia atlantica and Pistacia khinjuk

Abstract

Pistacia atlantica and Pistacia khinjuk are two major Pistacia species that grow in the Zagrossian region and classified into the Anacardiaceae family. In this work we investigated the drug properties of these plants. Experiments were carried out by extract of plants in vitro and in vivo (what kind of extract? both of them). In the in vitro experiments, antibacterial activity of four kinds of extract of P. atlantica and P. khinjuk were evaluated using the disk diffusion method on three strains of bacteria (Escherichia coli,Staphylococcus aureus and Staphylococcus epidermidis). All the tests were compared with the inhibitory effect of proper antibiotics commonly used against these bacteria (Gentamicin, Tobramycin and Kanamycin). The in vivo experiment was undertaken to assess the potential of methanolic extract of P. khinjuk in wound healing in wistar rats by using excision wound model. The results showed that extract of two plants had a beneficial drug property. These results suggested that P. khinjuk and P. atlantica possess compounds with wound healing and antibacterial activity properties.   Key words: Antibacterial activity, wound healing, Pistacia atlantica, Pistacia khinjuk.