Evaluation of antiarthritic activity of Coriander seed essential oil in Wistar albino rats

Abstract

Background: Arthritis is the diseases affecting all age groups with the worldwide prevalence of 3% and 20% in India. Drugs used for the management of arthritis have various adverse effects. Due to their low side effects, low costing, and ready availability the interest in producing herbal formulations for medicinal purposes is developed. Coriandrum sativum is a medicinal herb possessing many activities with anti-inflammatory action being one among them. Objectives: To evaluate antiarthritic effect of coriander seed essential oil (CSEO) using Complete Freunds adjuvant(CFA) induced arthritic model in wistar albino rats. Methods: 24 rats were divided into 4 groups and the Experimental arthritis was induced by injecting 0.1 ml of CFA into the subplantar area of the left hind paw. Vehicle and drugs (Indomethacin & CSEO) were given for 20 days to animals of all the group, the Joint diameter was measured at day 0, 3, 7, 14 & 21 days and IL 6, TNF a levels were measured baseline & day21 by ELISA kit. Results: Significant decrease in joint diameter and paw volume was seen within both the groups, but there was no statistical significance in joint diameter reduction among the groups. The TNF a levels were statistically reduced by CSEO group compared to Indomethacin group. Conclusion: CSEO has antiarthritic effect due to its anti-inflammatory property which needs to be evaluated further with different doses and histopathological correlation.