Abstract
Unlike human teeth, the incisors of rodents have the unique feature of continuous growth throughout the lifetime of the animal. As the tooth lengthens, angiogenesis in the tooth pulp correspondingly must progress throughout the entire length of the tooth pulp. This dynamic tissue can be used as a valuable tool for studying the effects of drugs on angiogenesis in adult animals. The goal of this study was to develop a reliable and reproducible method for evaluating the pharmacodynamic effects of a small molecule VEGFR-2 inhibitor on blood vessel density in adult rats using formalin fixed, paraffin embedded, decalcified rat incisors. (The J Histotechnol 32(1):21–25, 2009)Submitted June 20, 2008; accepted with revisions October 22, 2008
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.