Abstract
The present study was undertaken to evaluate the anti - ulcer properties of Abutilon indicum (AI) . Ethanolic ( AI E ) and aqueous extracts ( AIA) of AI were studied for their a bility to inh i bit the gastric lesions in pylorus ligation, aspirin and alcohol indu ced ulcer models in rats. In addition their effects on pH, wall mucus , total acidity and gastric acid output were recorded. The test drugs in the dose of 200 mg/kg were administered twice daily orally at 10:00 h and 16:00 h respectively for five days for g astro protective studies. Ranitidine was used as reference drug. Ethanolic and aqueous extracts of Abutilon indicum significantly inhibited the gastric lesions induced by pylorus ligation, aspirin and alcohol. The gastric volume and total acidity were foun d to be significantly reduced while the gastric pH and mucus contents were found to be increased as compared to control group. The present findings suggest that the antiulcer properties of A butilon indicum may be due to its effect on both offensive and def ensive factors . These results support the ethno medical uses of Abutilon indicum in the treatment of ulcer.
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