Abstract
Several nicotinic and isoniazid derivatives, most of them containing nitro groups were synthesized by our group, and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. The compound 11d exhibited the best result (1.2 µg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP). Therefore this class of compounds could be a good starting point to develop new lead compounds in the treatment of multi-drug resistant tuberculosis.
Highlights
The pyridine nucleus is an important heteroaromatic class of compounds with a wide range of activities and it is present in many products such as drugs, vitamins, food, flavorings, plants, dyes, rubber products, adhesives, insecticides and herbicides[1]
Of anti-tuberculosis first-line drug isoniazid[5], which is an analogue of isonicotinic acid, an isomer of nicotinic acid
Due to the importance of nicotinic acid derivatives and its isomers, the aim of this article is to evaluate the in vitro antibacterial activity against Mycobacterium tuberculosis of several compounds of this class synthesized by our group
Summary
The pyridine nucleus is an important heteroaromatic class of compounds with a wide range of activities and it is present in many products such as drugs, vitamins, food, flavorings, plants, dyes, rubber products, adhesives, insecticides and herbicides[1] In this context, nicotinic acid (pyridine-3-carboxylic acid), known as niacin and vitamin B3, is found in various plants and animals and has vital roles in such biological processes as production of energy, signal transduction, regulation of gene expression and synthesis of fatty acids, cholesterol and steroids[2,3]. Nicotinic acid derivatives and its isomers have been investigated as an agent for the prevention or delay of the onset of type 1 diabetes mellitus[4] They have anti-bacterial, anti-oxidant, anti-inflammatory and anti-carcinogenic activities, and have putative activity against osteoarthritis and granuloma annulare[3]. Due to the importance of nicotinic acid derivatives and its isomers, the aim of this article is to evaluate the in vitro antibacterial activity against Mycobacterium tuberculosis of several compounds of this class synthesized by our group
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
