Abstract
Acne vulgaris is one of the most common health problem where medical treatment is sought in adults worldwide. It has been long described the integral role of Propionibacterium acnes in the pathogenesis of this disease. In this study, a group of local herbs known for their antimicrobial effects were selected for the evaluation of potential anti-acnes effects in vitro. Phenolics and flavonoid contents of methanolic extracts of Eucalyptus globulus, Mentha rotundifolia, Inula viscosa, Utrica dioica, Malva sylvestris, Quercus calliprinos, Arum palaestinum and Achille aodorata collected from different regions in Jordan during 2016-2017 were screened for antimicrobial activity against Propionibacterium acnes by disc diffusion and by broth microdilution method. Measurement of release of interleukin 1 alpha from human skin explants by ELISA was used for the evaluation of anti-inflammatory effects of the herbal preparations and extracts. M. rotundifolia and E. globulus, showed the highest phenolic and flavonoid contents in contrast to M. sylvestris which showed the least phenolic contents. Moreover, polyphenolic fractions exhibited modest anti-acne activity of herbal extracts of E. globulus and A. palaestinum (MIC 0.125 mg/ml), U. dioica (0.25 mg/ml) and I. viscosa (0.5 mg/ml), compared to not significant antimicrobial activity for others (MIC >1mg/ml). Regarding anti-inflammatory effects of the tested fractions, E. globulus and A. palaestinum extracts showed inhibition of interleukin 1 alpha release by more than 60 % for concentrations of 0.5 mg/ml respectively. The presence of anti-inflammatory and anti-acne activities in the polyphenolic extracts of local medicinal plants would increase the potential of using these herbs in the control of Acne vulgaris.
Highlights
This study aims to determine the antimicrobial effects against P. acnes of polyphenolic extracts of methanolic extracts of Eucalyptus globulus, Mentharotundifolia, Inulaviscosa, Utricadioica, Malvasylvestris, Quercuscalliprinos, Arum palaestinumandAchilleaodorata collected from different regions in Jordan and their potential anti-inflammatory effects which, in our opinion, might provide new therapeutic options for the management of acne vulgaris
The present study, investigated the antimicrobial activity of polyphenolic extracts of eight local herbs including against P. acnes
Both A. palaestinum and U. dioica showed modest antimicrobial activities in comparison to other herbs which insignificantly affected the growth of P. acnes.Our results are in agreement with most of the studies conducted on the evaluation of biological activities of Eucalyptus extracts
Summary
This study aims to determine the antimicrobial effects against P. acnes of polyphenolic extracts of methanolic extracts of Eucalyptus globulus, Mentharotundifolia, Inulaviscosa, Utricadioica, Malvasylvestris, Quercuscalliprinos, Arum palaestinumandAchilleaodorata collected from different regions in Jordan and their potential anti-inflammatory effects which, in our opinion, might provide new therapeutic options for the management of acne vulgaris
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
