Abstract
Objective: The objective of the study was to evaluate the anti-oxytocic activity of ethanolic extract of Asparagus racemosus root.
 Methods: Ethanolic extract of A. racemosus root was taken by Soxhlet extraction method. Wistar strain albino non-pregnant female rats of weight 200–300 g were pre-treated with estrogen and were sacrificed to take their uterus. The tissue was then mounted in an organ bath containing de Jalon’s solution. The response of the tissue to various doses of oxytocin alone and then on adding increasing doses of the alcoholic extracts of A. racemosus along with the dose of oxytocin which produces sub-maximal contraction were recorded on a smoked drum.
 Results: Extract in doses up to 40 mg when given along with oxytocin 0.1 unit produced graded increase in contractions in rat uterus. From 80 mg onward graded blockade of contractions occurred with complete blockade at 200 mg. On complete removal of the extract by thorough washing, it was seen that oxytocin was again able to produce contractions of the rat uterus tissue.
 Conclusion: The ethanolic extract of A. racemosus root had demonstrated good anti-oxytocic property.
Highlights
Traditional medicine which uses plants as a source of drugs is gaining more importance nowadays
Ethanolic extract of A. racemosus in high doses acts as a partial agonist antagonizing the action of pure agonist oxytocin
Lot of toxicity studies done on asparagus racemosus showed that it is safe in high doses
Summary
Traditional medicine which uses plants as a source of drugs is gaining more importance nowadays. In developed world herbal medicines are nowadays widely used as nutraceuticals and food supplements for various ailments [3] Such preparations were vigorously marketed in the times of corona pandemic throughout the world. A. racemosus root is being used for the treatment of various ailments such as urinary tract infections, diarrhea, and dysentery because of its anti-microbial activity [4,5,6]. It is having good antibacterial activity against Gram-negative bacteria [7]. In this context, it was decided to test whether Shatavari is having any antioxytocic activity on rat uterus
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