Abstract
Gentiana lutea Linn (Gentianaceae), commonly known as gentian, is widely used in the traditional system of medicine as an anti-inflammatory and wound healing agent. We examined the effectiveness of alcohol and petrol ether extracts of rhizomes of Gentiana lutea at 500 and 1000 mg/kg doses orally in the carrageenan-induced rat paw edema, xylol-induced mouse ear edema and cotton pellet-induced chronic inflammatory models. Both extracts showed significant dose-dependent anti-inflammatory activities in all of these models. Both extracts exhibited significant wound healing activity at 300 and 500 mg/kg, p.o., in excision, resutured incision and dead space wound models.
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