Abstract
Objective: The objective of the study was to establish the anti-inflammatory and anti-arthritic potential of various fractions of Eclipta prostrata Linn.
 Methods: The four fractions, i.e., n-butanol, ethyl acetate, chloroform, and n-hexane from hydro-alcoholic extract were obtained. First, the fractions were evaluated through in vitro models, and then they were evaluated by in vivo anti-inflammatory model, i.e., carrageenan-induced paw edema model. Further, two active fractions were evaluated for the anti-arthritic activity using formaldehyde induced arthritis model.
 Results: The fractions at a dose of 100 and 200 mg/kg showed an anti-inflammatory activity, but the ethyl acetate and chloroform fraction will show maximum anti-inflammatory potential. Hence, they are further evaluated for anti-arthritic potential where they show significant activity.
 Conclusion: From the results, it is concluded that the ethyl acetate and chloroform fraction show significant anti-arthritic activity.
Highlights
Arthritis and diseases of joints have been plaguing humankind since times
Phytochemical analysis Pharmacologically active EPHF, EPCF, EPBF, and EPAF fractions were screened for the phytochemical study
Heat-induced hemolysis It is of particular concern to investigate the in vitro anti-inflammatory properties of medicinal plants, especially those traditionally used in folk medicine
Summary
Arthritis and diseases of joints have been plaguing humankind since times. There is an indication of rheumatoid arthritis (RA) in the Egyptian mummies, as found in several studies. Elliot, in his studies, found that RA was a prevalent disease among Egyptians [1]. In Indian literature, Charak Samhita (300–200 B.C.) described a clause that describes pain, joint swelling, and loss of joint morbidity, and functions. RA is a continual autoimmune disease characterized by joint swelling, synovial inflammation, and cartilage destruction and commonly leads to significant disability [2]. It affects about 1% of the population of the world
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