Abstract
The effect of extracts on inflammation were studied in formaldehyde, 12-O-tetradecanoylphorbol (TPA), carrageenan and histamine induced edema. In addition, cotton pellet granuloma test was used to investigate the effects of NS on inflammation. The hexane extract (NS) significantly inhibited paw edema induced by carrageenan, formaldehyde and histamine as well as ear edema induced by TPA in rat after oral or topical administration at doses of 50, 100 and 200mg/kg. The antiedema potency of hexane extract was compared with indomethacin, dexamethasone and diclofenac sodium as standard drugs indicated that extract had good anti-inflammatory activity. Taken together, these results suggest that NS exerts anti-inflammatory activity with the partial contribution of inhibitory action of some inflammatory responses. In conclusion, hexane extract from seeds of Byrsonima crassifolia effectively controls acute and chronic inflammation in experimental models, which can be mediated by reducing the release of mediators and weakening the inflammation effects of these mediators.
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