EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SIDDHA HERBO-MINERAL FORMULATION: SURANGUSA PARPAM

Abstract

Introduction: Medicinal plants, minerals and some marine products can potentially treat medical conditions in the long term based on error and trial methods. Surangusa parpam, one of the Siddha herbo-mineral formulations, is mentioned in the classical Siddha text and indicated for respiratory illnesses like cough, cold, fever, bronchial asthma and intestinal tuberculosis. Objectives: This study was designed to evaluate the anti-inflammatory activity of the trial drug Surangusa parpam. Materials and Methods: The trial drug Surangusa parpam is prepared as per literature and inflammation is induced in the experimental animal’s carrageenan-induced paw oedema model. The trial drug Surangusa parpam and standard indomethacin are given orally for the anti-inflammatory effects. The anti-inflammatory effects were measured at regular intervals, and the percentage of the inhibition of paw oedema was to compare the effect of the trial medicine with the control and standard. Results: The trial drug showed significant improvement in the percentage inhibition of paw oedema in graded doses compared to control in the carrageenan-induced paw oedema model. 15 and 35 mg/kg of the trial drug showed significant inhibition of paw oedema at 55.9 % and 58.9 % compared with the control. Conclusion: Anti-inflammatory activity is seen with the graded dose of the trial drug. It can be concluded that the herbo-mineral formulation showed significant anti-inflammatory activity.