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Abstract
<p><em>Naravelia zeylanica</em> DC (Ranunculaceae), a woody climber, have been used from ancient times to treat various ailments like rheumatoid arthritis, skin diseases, wound and ulcer. The present study was designed to investigate the anti-hyperglycemic activity of methanolic extract of <em>Naravelia zeylanica</em> (NZYM) using experimental diabetic model. Diabetes was induced in<strong> </strong>wistar rats by a single dose of streptozotocin (55 mg/kg i.p.) (STZ) and treated with NZYM at doses of 100 and 200 mg/kg for 45 days. Glibenclamide (5 mg/kg b.w.) was used as standard drug. Blood glucose and body weight were monitored at regular intervals and the levels of serum insulin, lipid and the carbohydrate metabolic enzyme in the liver were measured at the end of the study. Oral administration of NZYM and glibenclamide significantly reduced the blood glucose level (<em>p&lt;0.05</em>), with increased serum insulin and significant alteration in lipid profiles and liver carbohydrate enzymes (<em>p&lt;0.05</em>) after 45 days. Furthermore, the biochemical parameters correlated with the histopathological changes in the pancreas of STZ-induced diabetic rats, which structurally proved the efficacy of NZYM. The findings suggest that NZYM possess anti-hyperglycemic activity and anti-hyperlipidemic properties and restored STZ-induced pancreatic damage in diabetic rats. NZYM might therefore have a beneficial effect in treatment of diabetes mediated through regulation of carbohydrate metabolic enzyme activities. <strong></strong></p>
Highlights
Diabetes mellitus is a multi-factorial endocrine metabolic disorder characterized by deficiency in insulin or defects in insulin action in regulation of blood glucose or both
The effects of the oral administration of NZYM on body weight and blood glucose in normal and diabetic rats were represented in Table 1 & 2
The treatment of NZYM at both the doses showed a significant (p
Summary
Diabetes mellitus is a multi-factorial endocrine metabolic disorder characterized by deficiency in insulin or defects in insulin action in regulation of blood glucose or both. Current treatment strategy for the control of diabetes includes diet, exercise, oral hypoglycemic agent and insulin therapy. Much attention has been paid to research on anti-diabetic potential of medicinal plants, since the commercially available anti-diabetic drugs have various side effects [2]. Medicinal plants have been used traditionally in Indian system of Ayurveda, which provides a valuable source of oral hypoglycemic compounds for the DOI:10.5138/09750185.1825 development of new therapeutic strategies [5]. Few bioactive molecules extracted from medicinal plants have been documented for insulinomimetic or insulin secretagogue effects such as Saraca asoca [6], Selaginella tamariscina [7], Scoparia dulcis [8] and Gymnema montanum [9]. Based on the ethanopharmacological importance, the present study was focused on the evaluation of anti-hyperglycemic and anti-hyperlipidemic activity of NZYM in STZ-induced animal model
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