Evaluation of anti-hyperglycaemic and anti-hyper lipidemic activity of Commelina benghalensis leaves in STZ induced Diabetic rats

Abstract

Anti-hyper glycaemic and anti-hyper lipidemic activity of methanolic extract of CBME was investigated in STZ induced diabetic rats. Thirty male albino rats were intra peritoneally injected with streptozotocin at a concentration of 50mg/kgbwt to induce diabetes mellitus. The injected rats were divided into five groups and diabetic treated group was fed with methanolic extract of 500mg/kgbwt for 45 days. At the end of the treatment, animals were sacrificed by cervical dislocation and blood and organs were collected for biochemical and haematological analyses. Statistical significance (p<0.05) was evaluated by one way ANOVA. CBME at a dose of 500 mg/kg bwt produced significant anti-hyperglycaemic activity in diabetic rats. The long-term treatment with CBME in STZ induced diabetic rats showed significant improvement in glycaemic control along with decreased insulin resistance, increase in body weights and plasma insulin levels. In addition, CBME suppressed lipid peroxidation and replaced the activities of antioxidant enzymes in the liver and kidney to normal levels. This study confirmed that CBME exerts anti-hyper glycaemic and anti-hyper lipidemic effects in diabetic rats by improving insulin secretion, glycaemic control and restoring functional activities of the liver and kidney. Our results suggest that leaves of Commelina benghalensis can be used as a complementary or alternative agent for the treatment of diabetes mellitus.