Evaluation Of Anti-Fungal Potential Of Cinnamomum Zeylanicum Blume (Lauraceae) Barks Extract For Onychomycosis

Manivannan S,Bhuvaneswari S

doi:10.26524/krj301

Abstract

Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts of nondermatophyte molds. Far more than being a simple cosmetic problem, infected nail serves as a chronic reservoir, which can give rise to repeated mycotic infections and represents about 30% of mycotic cutaneous infections. Theprevalence rate of onychomycosis is determined by age, predisposing factor, social class, occupation, climate,living environment. To evaluation of Anti-fungal potential of Cinnamomum Zeylanicum Blume (Lauraceae) Barks Extract for Onychomycosis. The C. Zeylanicum barks crude extracts were obtained by soxhlet-solidliquid extraction using ethanol and aqueous. The dermatophytes namely, Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton simii, Epidermophyton floccosum and Candida albicans were recovered from rice farmers in Orathanadu, Thanjavur (Dt), Tamil Nadu. The antifungal activity, minimum inhibitory concentrations and minimum fungicidal concentrations against the onychomycosis of C. zeylanicum was determined by the disc diffusion methods in sabouraud dextrose agar using ketoconazole (2mg/disc) as a positive control. Phytochemical analysis revealed the presence of wide range of bioactive constituents like flavonoids, tannins, alkaloids, saponins, terpenes and steroids. The ethanol barks extract inhibited all test organisms at the minimum concentration of 25 mg/ml while fungicidal actions were observed at a concentration of 50 mg/ml for T. rubrum, 180 mg/ml for T. mentagrophytes, 160 mg/ml for T. simii, 120 mg/ml for E. floccosum and 60 mg/ml for C. albicans. The ability of the extracts to inhibit the growth of fungi likes dermatophytes and yeast is an indication of the antifungal potential of C. zylanicum, which makes the candidate for production of antifungal agents.

Highlights

Fungal nail infections are not life-Onychomycosis is an infection of the nail and may involve the nail bed, nail plate and matrix by fungi that include dermatophytes, nondermatohyte moulds and yeasts
The ethanol barks extract inhibited all test organisms at the minimum concentration of 25 mg/ml while fungicidal actions were observed at a concentration of 50 mg/ml for T. rubrum, 180 mg/ml for T. mentagrophytes, 160 mg/ml for T. simii, 120 mg/ml for E. floccosum and 60 mg/ml for C. albicans
The toenails are affected in 80% of all cases of onychomycosis; dermatophyte infection, mostly due to Trichophyton rubrum, is the cause in over 90% of cases. 5–10% of these infections are caused by yeasts, especially Candida albicans

Summary

Introduction

Onychomycosis is an infection of the nail and may involve the nail bed, nail plate and matrix by fungi that include dermatophytes, nondermatohyte moulds and yeasts. Onychomycosis is the most common condition affecting the nails, accounting for 50% of all nail disorders and 33.3% of all mycotic infections of the skin [1, 2]. The toenails are affected in 80% of all cases of onychomycosis; dermatophyte infection, mostly due to Trichophyton rubrum, is the cause in over 90% of cases. 5–10% of these infections are caused by yeasts, especially Candida albicans. Onychomycosis occurs in 10% of the general population the incidence of onychomycosis has been increasing, owing to such factors as diabetes, immunosuppression, and increasing age. Various workers have reported the incidence to vary from 0.5 to 5% in the general population in India [3]

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