Evaluation of Anti-Diabetic Activity of extract of Aegle Marmelos fruit and leaf in Wistar Rats

Abstract

Aim: The study was designed to evaluate the anti-diabetic properties of Aegle marmelos of dried juice. Methods: Anti-diabetic activity of hydroalcoholic extract of Aegle marmelos of dried juice on Alloxan (120 mg/kg) induced diabetic rats (21 days model) was carried out. The treatment (p.o.) was started on the same day except for normal control and diabetic control groups for a period of 7 days. Blood glucose level was estimated on the 1st, 7th, 14th and 21st days of the treatment. Glibenclamide (10 mg/kg) was used as a reference standard drug. Results: Anti-diabetic activity in Alloxan induced Hyperglycemic rats, a marked rise in blood glucose level observed in diabetic control compared to normal control rats. Test extract exhibited a significant dose-dependent antihyperglycemic activity compared to diabetic control. The effect of test extract on blood glucose levels seemed to be less potent than reference standard glibenclamide. Normal control animals were found to be stable in their body weight but diabetic rats showed a significant reduction in body weight during the treatment period. Alloxan Caused bodyweight reduction was significantly reversed by the extract at the dose of 100 mg/kg, 250 mg/kg and 500 mg/kg. in a dose-dependent fashion compared to diabetic control. The effect of the test extract was found lesser than the reference standard drug on the restoration of the altered body weight of rats. Conclusion: The result of the present study was indicated that Aegelmarmelos dried fruit juice extract possesses significant anti-diabetic activity against various experimentally induced diabetic models.