Abstract
The aim of this study was to analyze the effect of virgin coconut oil (VCO) on high lipid diet (HLD) and high carbohydrate diet (HCD) induced atherosclerosis in male Wistar rats. Spectrophotometer was used to determine the lipid parameters by enzymatic endpoint method. The plasma total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL) levels were measured using commercial enzymatic kits. The results showed that feeding with normal and VCO diet significantly decrease (p<0.05) body weight when compared to the control group rats. Body weight and lipid profile were estimated after 8 weeks of treatment. VCO showed a significant (p<0.05) reduction in TC, TG, Low density lipoprotein (LDL), Very low density lipoprotein (VLDL) levels and significant (p<0.05) increase in HDL in HCD /HLD group rats. There was significant decrease in atherogenic index (AI) (p<0.05) of all VCO treated groups when compared to the Control group. Hence, there was increase in the percentage of protection in VCO treated animals after 8 weeks.The decrease of lipid profiles in the experimental rats showed that VCO possesses anti-atherosclerotic activity.
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