Abstract
Capparis decidua has been traditionally used in the Ayurveda to treat rheumatoid arthritis and it is reported to have anti-inflammatory and analgesic activity. Considering its anti-inflammatory activity the present research work has been designed to assess the anti-arthritic activity in Wistar rats. The anti-arthritic activity of hydroalcoholic extract of C. decidua root, stem and leaves was evaluated using Freund's complete adjuvants (FCA) induced arthritic models in Wistar rats. Oral administration of C. decidua extract at the dose of 100mg/kg, 200mg/kg, per se group (only 200mg/kg of C. decidua) was subjected to Wistar rats for 28 days. Standard drug Diclofenac sodium at the dose of 5mg/kg and FCA at 1mg/ml was used in the study. The normal control group was administered only distilled water at 1ml/kg without induction of arthritis. The arthritic investigation was carried out on basis of parameters including changes in body weight, paw volume, hematological studies like ESR count, RBC count, WBC count, Hemoglobin count, platelet count. At the end of study period, animals were sacrificed and histological parameters were evaluated. Phytochemical analysis of C. decidua extract was done to assess the various constituents present in C. decidua. The results of C. decidua extract administration significantly (P<0.001) attenuated the body weight, paw volume, hematological alteration induced by the FCA in dose-dependent manner. The tarsal joint was extracted for histopathological studies. The overall results indicate that C. decidua extract (100mg/kg and 200mg/kg) showed a potent protective effect against FCA induced arthritic rats which could be attributed to phytoconstituents present in C. decidua and its effect is comparable to the standard drug diclofenac sodium.
Highlights
Joint inflammation and related issue, including rheumatoid arthritis (RA), are normal illnesses influencing a great many individuals
The dose of hydroalcoholic extract of C. decidua was selected on this basis and as per the earlier studies conducted by Goyal et al 2009 [7] where 100mg/kg and 200mg/kg of C. decidua showed significant results (P
The effect produced by C. decidua extract at 100 mg/kg and 200mg/kg produced a similar result as seen in a diclofenac-treated group on days 17, 21, 24 and 28. (Figure 1)
Summary
Joint inflammation and related issue, including rheumatoid arthritis (RA), are normal illnesses influencing a great many individuals. The fundamental classes of medications used to treat rheumatoid joint inflammation are analgesics, disease-modifying antirheumatic drugs (DMARDs), non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppressive drugs. In any case, these medications deliver some undesirable symptoms, for example gastrointestinal ulcergenicity and renal morbidity. Capparis decidua Edgew., belonging to the family Capparidaceae, is a glabrous, highly branched, spiny, spiked, relatively leafless bush or little tree developing fiercely in dry, open badlands all through the parched and semi-dry zones of India and diverse parts of the world It is commonly called as Kair, or Karil [4]. The collected extract was stored in a sterile container for further use
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