Evaluation of Anthelmintic Activity of Caesalpinia Pulcherrima Leaf Extract by In-Silico and In-Vitro Studies

Abstract

The Greek term for "helminthes" means "worm." Human-infecting parasites fall into one of two categories: keepsakes or heirlooms. Heirlooms are parasites that have been passed down from African ancestors, while souvenirs are parasites that humans have picked up from animals through migration, evolution, and agricultural activities. These helminthic infections are the most prevalent human infectious agents in poor nations. The helminthic parasite affects around 2 billion people worldwide, or more than 25% of the total population. It is a big problem in developing nations, particularly for young people. Therefore, the goal of the current study was to extract the plant's active ingredients and test the crude extract's anti-helminthic properties. In this study, we worked on the ceasalpeniapulcherima plant with a focus on natural remedies for the treatment of helmintiasis. The chief scientist of Sri Konda Laxman Telangana State Horticulture University, Floriculture Research Station, Rajndranagar, authenticated the true nature of the plant. Water and ethanol were utilized in the extraction procedure. To find out what chemicals are in the alcoholic extract, a screening test is performed on it. The flavonoid test on the extract came out positive. Using Albendazole as the prescribed medication, the anthelmintic action was carried out on Indian earthworms. In Indian earth worms, we found that alcoholic extract exhibits good antihelmintic action. By Insilco studies we found the interaction of flavanoids with antihelmentic proteins. Key Word: Helminthes, ceasalpeniapulcherima, flavonoids, extractioin, in silico study.