Evaluation of Angiopoietin One and Angiopoietin Two with Missed Abortion

Abstract

Missed abortion (MA) is a type of miscarriage, refer to pregnancy in which there is fetal demise without intervention, and also uterine that may expel the product of conception prior to 20 weeks of gestation to assess the role of ANG1 and ANG2 level in early pregnancy and compare these level with healthy pregnancy women, ANG1 play role in new blood vessels maturation and stabilization, the inhibition of endothelial apoptosis and reduction of vascular permeability in stable environment. ANG2 is an antagonist of ANG1 and it known to enhance the plasticity, destabilization and permeability of blood vessels and vascular remodeling site. A prospective cross - study, all women were attended to obstetrics and gynecology outpatient,and this study was carried out from Jan 2019 to July 2019. Sixty Women with missed miscarriage fetus heart negative 6-8 weeks were screened to participate in the present study group, Ages were between 18 – 35 years old, and they were from center and the periphery of Kirkuk city to comparative forty apparently health women with early pregnancy fetus heart positive a control groups. A serum level of ANG1 and ANG2 was measured by ELIZA. The result shows that the mean serum level of Angiopoietin one was significantly decrease in missed mischarge compared to control women (2.92±2.4 vs. 5.6±3.2 ng/ml) respectively at a P < 0.05. And this study showed that there was the significant decrease serum level of angiopoietin two in missed miscarriage patients compared with the control group women (8.12±3.5 vs. 16.81 ±12.3). This study showed that there were the positive correlations of Angiopoietin one and two with missed miscarriage. It can be conclude that the level of serum Angiopoietin -1 and level of serum angiopoietin -2 in missed abortion decrease and it is can be used as an early and effective biomarker for diagnosis of missed abortion.