Evaluation of analgesic , anti-inflammatory and CNS activities of the methanolic extract of Syzygium Samarangense bark.

Abstract

2 Abstract: Syzygium Samarangense is a potential medicinal drug. We aimed to evaluate the analgesic, anti- inflammatory and CNS activities of the methanolic extract of Syzygium Samarangense leave in mice. The analgesic activity was examined by acetic acid induced writhing and formalin tests. The anti-inflammatory activity was studied using carrageenan induced hind paw edema model. The analgesic activity of the methanolic extract of Syzygium Samarangense leaves was evaluated by acetic acid induced writhing and formalin tests at the dose of 100 mg/kg and 200 mg/kg, significantly (p<0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. The extract of Syzygium Samarangense leaves caused significant (p <0.05) inhibition of carrageenan induced paw edema after 4 hrs in a dose dependent manner. The CNS depressant activity was evaluated by observing the reduction of locomotor and exploratory activities in the open field and hole cross tests at a dose of 100 mg/kg and 200 mg/kg body weight. The findings of the study suggested that the methanolic extract of Syzygium Samarangense leave has remarkable analgesic, moderate effect against inflammation and significant CNS effects, conforming the traditional use of this plant for inflammatory pain alleviation.