Evaluation Of Analgesic And Anti Inflammatory Activity Of Siddha Drug Karuvilanchi Ver Chooranam (Root Powder Of Smilax Zeylanica Linn) In Rodents

Abstract

The present study was carried out to validate the anti-inflammatory and analgesic activities of Karuvilanchi ver chooranam (KVC) (Root powder of Smilax zeylanica) in rodents. Analgesic study was carried out by using Eddy's Hotplate method and acetic acid-induced writhing test and Anti inflammatory study was evaluated by Cotton pellet granuloma method and by plethysmometer method. The result of the analgesic activity evaluated using hot plate method revealed that the reaction time for mice was significantly increased in a dose dependent manner after one hour of oral administration. It was found that both KVC and Aspirin caused an inhibition on the writhing response induced by acetic acid. Doses of 250 and 500 mg/kg of the KVC and aspirin respectively, could completely block the writhing response exhibited about 61.51 and 72.51% inhibition. In acute inflammation model, the formalin induced paw oedema was significantly reduced by all the doses of KVC used when compared to control (P<0.05). The results of cotton pellet granuloma method indicated that KVC in both doses significantly reduced the weight of the cotton pellet granuloma with a dose dependent effect. From the result it can be concluded that the trial drug Karuvilanchi Ver Chooranam has potent analgesic and anti inflammatory properties which confirmed the traditional use.