Abstract
Eremostachys laciniata (L.) Bunge (family: Lamiaceae) is one of the fifteen endemic Iranian herbs of the genus Eremostachys , and also grows in other central and western Asian countries. In the Iranian traditional medicine, this plant has been used as a local analgesic and as an anti-inflammatory remedy. In the present study, the methanol (MeOH) extract of the rhizomes of E. laciniata as well as the solid-phase extraction (SPE) fractions have been evaluated for their analgesic property in mice using the hot-plate test. All doses of the SPE 20% aq. MeOH fraction (P < 0.01) and the MeOH extract at the doses of 0.5 mg/kg (P < 0.01) and 1 mg/kg (P<0.05) displayed considerable analgesic effects. The analgesic effect of the SPE 20% aq. MeOH fraction (2.5 mg/kg) was more potent than that of the positive control, morphine (9 mg/kg) at 45 min after injection (P<0.001). However, SPE 40% aq. MeOH fraction did not show any analgesic effects at test doses.
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