Abstract
Background: The addition of Magnesium sulphate (MgSO4) to postoperative Fentanyl Epidural infusions has been demonstrated to reduce the requirement for Fentanyl. Methodology: Group I (38 patients) got Epidural Fentanyl 50 mg (1 cc) diluted and made up to 6 cc with normal saline, whereas Group II (38 patients) received Epidural Fentanyl 50 μg (1 cc) + MgSO4 50 mg (4 units in insulin syringe of 50% solution) diluted and made up to 6 cc with normal saline. The effects of analgesia on pulse rate and blood pressure were measured as well as the duration of analgesia. Results: In this study, an average age of the study population was 41.25 ± 3.25 years in Group I and 42.14 ± 4.42 years in Group II. The pulse rate in Group-I increased significantly from 105 minutes compared to Group-II, whereas it remained steady in Group-II throughout the research duration. Systolic BP increased significantly in Group-I after 90 minutes compared to Group-II, but remained steady in Group-II. SPO2 and respiratory rates did not differ significantly.Conclusion: Adding magnesium sulphate to fentanyl in epidural analgesia increased the duration of analgesia while maintaining hemodynamic stability.
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