Abstract
The purpose of this study was to investigate the effectiveness of a resorbable alloplastic in situ hardening bone grafting material for alveolar ridge preservation in a swine model. Seven Landrace pigs were used. In each animal, the maxillary left and right deciduous second molars were extracted, and extraction sites were either grafted with a resorbable alloplastic in situ hardening bone substitute, composed of beta-tricalcium phosphate (β-TCP) granules coated with poly(lactic-co-glycolic) acid (PLGA), or left unfilled to heal spontaneously. Animals were euthanized after 12 weeks, and the bone tissue was analyzed histologically and histomorphometrically. Linear changes of ridge width were also clinically measured and analyzed. Pronounced bone regeneration was found in both experimental and control sites, with no statistically significant differences. At the experimental sites, most of the alloplastic grafting material was resorbed and remnants of the graft particles were severely decreased in size. Moreover, experimental sites showed, in a statistically nonsignificant way, less mean horizontal dimensional reduction of the alveolar ridge (7.69%) compared to the control sites (8.86%). In conclusion, the β-TCP/PLGA biomaterial performed well as a biocompatible resorbable in situ hardening bone substitute when placed in intact extraction sockets in this animal model.
Highlights
Clinical trials and experimental preclinical studies have shown that the grafting of extraction sockets constitutes a predictable and reliable way to preserve the dimensions and architecture of the alveolar ridge [1,2,3,4,5,6]
Experimental extraction sites grafted with the alloplastic bone substitute showed less mean horizontal dimensional reduction of the alveolar ridge compared to sites subjected to spontaneous healing
We investigated the effects of filling extraction sites in a swine model with a resorbable alloplastic in situ hardening bone grafting material
Summary
Clinical trials and experimental preclinical studies have shown that the grafting of extraction sockets constitutes a predictable and reliable way to preserve the dimensions and architecture of the alveolar ridge [1,2,3,4,5,6]. Such measures involve the use of different kinds of bone grafts, barrier membranes and growth-factor preparations, and many different surgical techniques and protocols. It should have satisfactory mechanical properties and no risk of disease transmission
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