Abstract
Objective. To evaluate the effect of an experimental gel containing Euclea natalensis extract on dentin permeability. Methods. Thirty-six dentin discs, 1-mm-thick. The discs were prepared from the coronal dentin of extracted human third molars that were divided into 3 groups (n = 10). The dentin discs in each group were treated with the groups following experimental materials: (FG): 1.23% fluoride gel, pH 4.1; (EG): Euclea natalensis extract gel, pH 4.1; (CG): control gel, pH 4.1. The gels were applied to the occlusal slide of the dentin under the following conditions: after 37% phosphoric acid and before 6% citric acid. The hydraulic conductance (HC) of each condition was determined four times using a fluid flow apparatus (Flodec). The data were analyzed using Two-way ANOVA and Tukey's test (P < 0.05). Results. The greatest mean reduction in HC was produced in group EG dentin discs (61.2%; P < 0.05). Even after acid challenge with 6% citric acid the great reduction occurred in group EG (66.0%; P < 0.05) than other groups (CG-77.1%, FG-90.8%). Conclusion. E. natalensis gel not only reduced dentin permeability, but also resisted posttreatment citric acid challenge without changing its permeability. Further research has to confirm this promising result in the clinical situation.
Highlights
Dentin hypersensitivity is a painful clinical condition, which affects between 4 and 5% of the adult population and is associated with dentin exposure to the oral environment [1,2,3]
The effectiveness of the three gels in reducing dentin permeability was analyzed by performing ANOVA for two criteria (P < 0.05) (Table 2)
The results showed that the procedures caused some reduction in the hydraulic conductance of dentin etched with phosphoric acid, the groups presented significant reduction when compared with each other (P < 0.05)
Summary
Dentin hypersensitivity is a painful clinical condition, which affects between 4 and 5% of the adult population and is associated with dentin exposure to the oral environment [1,2,3]. The hydrodynamic theory predicts that exposure of dentin surfaces as a result of enamel loss and/or gingival root surface exposure resulting from attrition, abrasion, erosion, abfraction, or gingival recession can cause sensitivity [3, 4]. The fact that many of the agents clinically used to desensitize dentine are effective in reducing dentin permeability tends to support the hydrodynamic theory [6]. In the field of oral health researches, investigations about the contribution of natural products to the treatment of different oral diseases, such as propolis [8] and neem [9], have used experimental formulations and found that they did not cause significant side effects
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