Abstract
An evaluation of different methods of investigating the flow properties of bulk solids has been carried out on two new direct compression excipients, Ludipress ® and Maltrin ® M150, in order to establish a better validation of the study of the flowability of pharmaceutical powders according to their characteristics. A good correlation among all the methods was found. Also, both excipients showed different behavior, maybe due to the stickiness of Maltrin ® M150 and the size and shape of its particles. Finally, as far as an appropriate procedure is concerned, the most suitable method of estimating the flowability of powders is based on the flow rate system design, however, if it does not flow the shear cell method provides useful information about the reasons why this is so.
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