Abstract
Natural binders like different starches, gums, mucilages dried fruits possess binding capacity as well as some other properties like disintegrant, filler, sustain release, and these natural polymers are much safer and economical than polymers like PVP. The aim of the work was to evaluate utility of Aloe vera and Hibiscus rosa-sinensis mucilage as a binder in different tablet formulations containing Paracetamol as a model drug. Comparative evaluation of the prepared Paracetamol tablets (using Aloe Vera and Hibiscus rosa-sinensis mucilage as a binder) with the tablets manufactured using Microcrystalline cellulose as a binder. The results of the study revealed that mucilage from Hibiscus rosa sinensis and Aloe vera when utilized as a novel binder exhibited appropriate drug release pattern for conventional oral tablets of Paracetamol. Thus, it can be concluded that Hibiscus rosa sinensis and Aloe vera mucilage may be used as a binder in tablet formulation and possess a high potential for substitution for other more expensive binders.
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